ESRP2
Function
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Sequence Similarities
Belongs to the ESRP family.
Tissue Specificity
Epithelial cell-specific.
Cellular localization
- Nucleus
Alternative names
RBM35B, PP7059, ESRP2, Epithelial splicing regulatory protein 2, RNA-binding motif protein 35B, RNA-binding protein 35B