esxA
Function
A secreted protein. Acts as a strong host T-cell antigen. Plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm.
Sequence Similarities
Belongs to the WXG100 family. ESAT-6 subfamily.
Cellular localization
- Secreted
- Host membrane
- Probably secreted via the ESX-1 / type VII secretion system (T7SS). A central pair of alpha helices probably insert into host membrane.
Alternative names
esaT6, MT3989, esxA, 6 kDa early secretory antigenic target, ESAT-6