esxR
Domain
In the heterotetrameric form, EsxS adopts a long helical conformation that pairs with a second EsxS monomer in an antiparallel manner that allows the N- and C-termini of two EsxS subunits to interact with an EsxR subunit at each end of the EsxS dimer thus creating a molecule with four-helix bundles at its extremities.
Sequence Similarities
Belongs to the WXG100 family. ESAT-6 subfamily.
Cellular localization
- Secreted
- Probably secreted via the ESX-3 / type VII secretion system (T7SS).
Alternative names
Rv3019c, MTV012.33c, esxR, ESAT-6-like protein EsxR, TB10.3