ETAA1
Domain
The RBM1 (RPA1-binding, also named RPA70N-binding) motif mediates interaction with RPA1 (PubMed:27601467, PubMed:27723717, PubMed:27723720). The RBM2 (RPA2-binding, also named RPA32C-binding) motif mediates interaction with RPA2 (PubMed:27601467, PubMed:27723717, PubMed:27723720).
The ATR-activation domain (AAD) motif is required to bind and activate ATR (PubMed:27723717, PubMed:27723720).
Function
Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1 (PubMed:27723717, PubMed:27723720, PubMed:30139873). Probably only regulates a subset of ATR targets (PubMed:27723717, PubMed:27723720).
Post-translational modifications
Phosphorylated by ATR.
Tissue Specificity
Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.
Cellular localization
- Nucleus
- Localizes at sites of DNA damage following replication stress (PubMed:27601467, PubMed:27723717, PubMed:27723720). Recruited to stalled replication forks via interaction with RPA1 and RPA2 subunits of the RPA complex (PubMed:27601467, PubMed:27723720).
Alternative names
ETAA16, ETAA1, Ewing's tumor-associated antigen 1, Ewing's tumor-associated antigen 16