ETV5
GeneName
ETV5
Summary
ETV5, also known as ERM, is a 58 kDa transcription factor that plays a vital role in regulating gene expression through its DNA-binding capabilities. It is predominantly localised in the nucleus, where it associates with chromatin and nucleoplasm, and is involved in various biological processes including cell differentiation, neuromuscular synaptic transmission, and the regulation of neuron differentiation. ETV5 is implicated in the transcriptional regulation of RNA polymerase II, influencing both positive and negative transcriptional activities. Additionally, it has roles in male germ-line stem cell asymmetric division and glial cell proliferation, reflecting its importance in developmental and neurobiological contexts.
Importance
ETV5 is relevant to: - Understanding mechanisms of cell differentiation and development, particularly in the nervous system and muscle tissue - Investigating the molecular basis of neuromuscular disorders due to its role in synaptic transmission - Exploring its involvement in oxidative stress responses, which may have implications for neurodegenerative diseases - Studying its regulatory effects on mammary gland development and potential links to breast cancer biology
Top Products
For researchers investigating ETV5, we recommend the well-cited polyclonal antibody, Anti-ERM / Etv5 antibody (ab102010). This antibody has garnered 31 citations, highlighting its reliability and trust within the research community. It is particularly effective for Western blotting (WB) and immunocytochemistry (ICC), making it a valuable tool for various experimental applications. This product is an excellent choice for those looking to study ETV5 with confidence in their results.
Abcam Product Citation Summary
The data indicates that ETV5 is being studied in various contexts related to both spermatogonial phenotype retention and TFH cell differentiation. The use of Abcam antibody ab102010 in both immunocytochemistry and western blotting across different species, particularly in mouse and human prostate cell lines, highlights its relevance in oncogenic research and immune cell studies.
Abcam Product Citation Table
Function
Binds to DNA sequences containing the consensus nucleotide core sequence 5'-GGAA.-3'.
Sequence Similarities
Belongs to the ETS family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
Alternative names
ERM, ETV5, ETS translocation variant 5, Ets-related protein ERM