EXOC1
Function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
(Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.
Sequence Similarities
Belongs to the SEC3 family.
Cellular localization
- Midbody
- Midbody ring
- Cytoplasm
- Cytoplasm
- Perinuclear region
- Cell membrane
- Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214). Localizes in cell membrane in the presence of SLC6A9 (PubMed:16181645).
Alternative names
SEC3, SEC3L1, BM-012, EXOC1, Exocyst complex component 1, Exocyst complex component Sec3