EXOC6
Function
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity).
Sequence Similarities
Belongs to the SEC15 family.
Cellular localization
- Cytoplasm
- Cytoplasm
- Perinuclear region
- Cell projection
- Growth cone
- Midbody
- Midbody ring
- Perinuclear in undifferentiated cells. Redistributes to growing neurites and growth cones during neuronal differentiation. Colocalizes with CNTRL/centriolin at the midbody ring (PubMed:16213214).
Alternative names
SEC15A, SEC15L, SEC15L1, EXOC6, Exocyst complex component 6, Exocyst complex component Sec15A, SEC15-like protein 1