Extracellular superoxide dismutase [Cu-Zn]
Function
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Sequence Similarities
Belongs to the Cu-Zn superoxide dismutase family.
Tissue Specificity
Expressed in blood vessels, heart, lung, kidney and placenta. Major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
Cellular localization
- Secreted
- Extracellular space
- Golgi apparatus
- trans-Golgi network
- 99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
Alternative names
Extracellular superoxide dismutase [Cu-Zn], EC-SOD, SOD3