Ezhip
Function
Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation at 'Lys-27' (H3K27me3) (PubMed:31086175). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (By similarity). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (PubMed:31451685).
Tissue Specificity
Highly expressed in ovary with lower expression in testis and very low levels in other tissues tested including prostate, brain, kidney, spleen and liver (PubMed:31451685). During spermatogenesis, expressed mainly in spermatogonia with very low expression in spermatocytes I and II (PubMed:31451685).
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
AU022751, KIP75, Ezhip, EZH inhibitory protein, K27M-like inhibitor of PRC2