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EZR

OverviewProducts

Developmental stage

Very strong staining is detected in the Purkinje cell layer and in part of the molecular layer of the infant brain compared to adult brain.

Domain

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.

Post-translational modifications

Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity).

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.

Tissue specificity

Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.

Cellular localization

  • Apical cell membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Cell projection
  • Cell projection
  • Microvillus membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Cell projection
  • Ruffle membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Cytoplasm
  • Cell cortex
  • Cytoplasm
  • Cytoskeleton
  • Cell projection
  • Microvillus
  • Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).

Alternative names

  • Ezrin
  • Cytovillin
  • Villin-2
  • p81
  • EZR
  • VIL2

Database links

Target type

Proteins

Molecular weight

69413Da