F-BAR domain only protein 2
Function
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
Post-translational modifications
Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity).
Sequence Similarities
Belongs to the FCHO family.
Cellular localization
- Membrane
- Clathrin-coated pit
- Peripheral membrane protein
- Cytoplasmic side
- Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity).
Alternative names
F-BAR domain only protein 2, FCHO2