F-BAR domain only protein 2

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination (By similarity).

Belongs to the FCHO family.

• Membrane
• Clathrin-coated pit
• Peripheral membrane protein
• Cytoplasmic side
• Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2 (By similarity).

F-BAR domain only protein 2, FCHO2

• entrezGene:115548
• omim:613438
• swissprot:Q0JRZ9

Proteins

Neuroscience

88924Da