F-box only protein 32
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1.
Involvement in disease
Defects in FBXO32 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.
Pathway
Protein modification; protein ubiquitination.
Tissue Specificity
Specifically expressed in cardiac and skeletal muscle.
Cellular localization
- Cytoplasm
- Nucleus
- Shuttles between cytoplasm and the nucleus.
Alternative names
F-box only protein 32, Atrogin-1, Muscle atrophy F-box protein, MAFbx, FBXO32