F
Domain
Fusion glycoprotein F0
The N-terminus is a hydrophobic fusion peptide that inserts into the target host membrane (By similarity). It is buried in the center of the trimer cavity before cleavage. The coiled coil (heptad repeat) regions are probably involved in homotrimerization, heterodimerization and in the formation of a fusion-active hairpin structure (By similarity).
Fusion glycoprotein F1
The N-terminus is a hydrophobic fusion peptide that inserts into the target host membrane (By similarity). It is buried in the center of the trimer cavity before cleavage. The coiled coil (heptad repeat) regions are probably involved in homotrimerization, heterodimerization and in the formation of a fusion-active hairpin structure (By similarity).
Function
Fusion glycoprotein F0
Inactive precursor that is cleaved to give rise to the mature F1 and F2 fusion glycoproteins.
Fusion glycoprotein F1
Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the coiled coil regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs at the plasma or endosomal membrane. The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate.
Fusion glycoprotein F2
Major determinant of the species specificity of RSV infection (By similarity). The trimer of F1-F2 (F protein) also facilitates the attachment to host cell by binding to host heparan sulfate (PubMed:22238303).
Post-translational modifications
Fusion glycoprotein F0
The F glycoprotein is synthesized as a F0 inactive precursor that is heavily N-glycosylated and processed.
Sequence Similarities
Belongs to the paramyxoviruses fusion glycoprotein family.
Cellular localization
- Virion membrane
- Single-pass type I membrane protein
- Host cell membrane
- Single-pass membrane protein
Alternative names
Fusion glycoprotein F0, Protein F, F