F11r
Domain
The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11447115). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (PubMed:11447115). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (PubMed:9660867). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity).
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Cellular localization
- Cell junction
- Tight junction
- Cell membrane
- Single-pass type I membrane protein
- Localized at tight junctions of both epithelial and endothelial cells.
Alternative names
CD321, Jam1, Jcam, Jcam1, F11r, Junctional adhesion molecule A, JAM-A, Junctional adhesion molecule 1, JAM-1