F11R
Domain
The Ig-like V-type 2 domain is necessary and sufficient for interaction with integrin alpha-L/beta-2.
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11489913). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (By similarity). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (PubMed:11812992). Involved in platelet activation (PubMed:10753840).
(Microbial infection) Acts as a receptor for Mammalian reovirus sigma-1.
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Post-translational modifications
N-glycosylated.
(Microbial infection) Cleaved by H.pylori virulence factor PqqE. Cleavage leads to altered tight junction functions.
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Tissue Specificity
Expressed in endothelium, epithelium and leukocytes (at protein level).
Cellular localization
- Cell junction
- Tight junction
- Cell membrane
- Single-pass type I membrane protein
- Localized at tight junctions of both epithelial and endothelial cells.
Alternative names
CD321, JAM1, JCAM, UNQ264/PRO301, F11R, Junctional adhesion molecule A, JAM-A, Junctional adhesion molecule 1, Platelet F11 receptor, Platelet adhesion molecule 1, JAM-1, PAM-1