F13A1
Function
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
Involvement in disease
Factor XIII subunit A deficiency
FA13AD
An autosomal recessive hematologic disorder characterized by a life-long bleeding tendency, impaired wound healing and spontaneous abortion in affected women.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
The activation peptide is released by thrombin.
Sequence Similarities
Belongs to the transglutaminase superfamily. Transglutaminase family.
Cellular localization
- Cytoplasm
- Secreted
- Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.
Alternative names
F13A, F13A1, Coagulation factor XIII A chain, Coagulation factor XIIIa, Protein-glutamine gamma-glutamyltransferase A chain, Transglutaminase A chain