F2RL2
Function
Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.
Post-translational modifications
A proteolytic cleavage generates a new N-terminus that functions as a tethered ligand.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Highest expression in the megakaryocytes of the bone marrow, lower in mature megakaryocytes, in platelets and in a variety of other tissues such as heart and gut.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
PAR3, F2RL2, Proteinase-activated receptor 3, PAR-3, Coagulation factor II receptor-like 2, Thrombin receptor-like 2