F3
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Sequence Similarities
Belongs to the tissue factor family.
Tissue Specificity
Brain, heart.
Cellular localization
- Membrane
- Single-pass type I membrane protein
Alternative names
CD142, Tissue factor, TF, Coagulation factor III, F3