F3
GeneName
F3
Summary
F3, also known as tissue factor or thromboplastin, is a 33 kDa transmembrane glycoprotein that is predominantly expressed on the surface of endothelial cells and various other tissues. It plays a crucial role in initiating the extrinsic pathway of blood coagulation by binding to factor VIIa, leading to the activation of the clotting cascade. F3 is localised to the plasma membrane and the extracellular space, and it is involved in several biological processes, including the regulation of angiogenesis, cell migration, and inflammatory responses. Additionally, it has roles in cytokine-mediated signalling and the positive regulation of gene expression and interleukin-8 production.
Importance
F3 is relevant to: - Coagulation disorders and thrombosis due to its essential role in blood coagulation pathways - Cancer biology, as it is implicated in tumour angiogenesis and metastasis - Inflammatory diseases, given its involvement in acute inflammatory responses and cytokine signalling - Cardiovascular diseases, as it contributes to vascular integrity and responses to injury
Top Products
For researchers investigating F3, we highly recommend the top-selling recombinant antibody, Anti-Tissue Factor antibody [EPR22548-232] (ab228968). This antibody has been validated in knockout models, ensuring reliable performance in various applications, including Western blotting (WB), flow cytometry (FC), immunohistochemistry (IHC), immunocytochemistry (ICC), and immunoprecipitation (IP). With 14 citations, it is well-regarded in the research community, making it an excellent choice for those seeking consistent and effective detection of Tissue Factor. The Recombinant Human Tissue Factor protein ELISA Kit (ab119148) is an excellent option for researchers looking to measure F3 in their experiments.
Abcam Product Citation Summary
The data indicates that F3 is being studied in the context of inflammation and coagulation. Research involving mouse models highlights its role in septic death and hyperinflammation, while studies in human cells focus on its quantification in relation to coagulation factors.
Abcam Product Citation Table
Function
Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.
Sequence Similarities
Belongs to the tissue factor family.
Tissue Specificity
Lung, placenta and pancreas.
Cellular localization
- Isoform 1
- Membrane
- Single-pass type I membrane protein
- Isoform 2
- Secreted
Alternative names
CD142, Tissue factor, TF, Coagulation factor III, Thromboplastin, F3