F7
Function
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium (By similarity).
Post-translational modifications
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Can be either O-glucosylated or O-xylosylated at Ser-93 by POGLUT1.
Sequence Similarities
Belongs to the peptidase S1 family.
Tissue Specificity
Plasma and liver.
Cellular localization
- Secreted
Alternative names
Cf7, F7, Coagulation factor VII, Serum prothrombin conversion accelerator