F8a1

RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes (By similarity). The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility (PubMed:16476778).

Produced abundantly in a wide variety of cell types.

• Cytoplasm
• Nucleus
• Early endosome
• Nucleus
• Nuclear body
• Diffuse presence in the cytoplasm and accumulation in the nucleus (By similarity). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (PubMed:11035034). Colocalized with HTT in endosomes (By similarity). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (PubMed:23749422).

F8a, Hap40, F8a1, 40-kDa huntingtin-associated protein, CpG island protein, Factor VIII intron 22 protein

• swissprot:Q00558

Proteins

Neuroscience

40490Da