FAAH2
Function
Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
Sequence Similarities
Belongs to the amidase family.
Tissue Specificity
Expressed in kidney, liver, lung, prostate, heart and ovary.
Cellular localization
- Membrane
- Single-pass membrane protein
- Lipid droplet
Alternative names
AMDD, FAAH2, Fatty-acid amide hydrolase 2, Amidase domain-containing protein, Anandamide amidohydrolase 2, Oleamide hydrolase 2