FAAP20

The UBZ2-type zinc finger binds both 'Lys-48'- and 'Lys-63'-linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

• Nucleus
• Chromosome
• Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.

C1orf86, FP7162, FAAP20, Fanconi anemia core complex-associated protein 20, FANCA-associated protein of 20 kDa, Fanconi anemia-associated protein of 20 kDa

• entrezGene:199990
• omim:615183
• swissprot:Q6NZ36

Proteins

Oncology

19869Da