FABP2
Domain
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Function
FABPs are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Sequence Similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Tissue Specificity
Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.
Cellular localization
- Cytoplasm
Alternative names
FABPI, FABP2, Fatty acid-binding protein 2, Intestinal-type fatty acid-binding protein, I-FABP