Fabp4
Domain
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
Function
Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus.
Sequence Similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Cellular localization
- Cytoplasm
- Nucleus
- Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus (PubMed:17516629). Subject to constitutive nuclear export (PubMed:17516629, PubMed:17761196).
Alternative names
Ap2, Fabp4, 3T3-L1 lipid-binding protein, Adipocyte lipid-binding protein, Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Myelin P2 protein homolog, P15, P2 adipocyte protein, Protein 422, ALBP, A-FABP, AFABP