FABP5

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (By similarity). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity).

Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

• Cytoplasm
• Nucleus
• Synapse
• Postsynaptic density
• Secreted
• Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (By similarity). Secreted by astrocytes, but not by neurons (By similarity).

Fatty acid-binding protein 5, Cutaneous fatty acid-binding protein, DA11, Epidermal-type fatty acid-binding protein, C-FABP, E-FABP, Fabp5

• swissprot:P55053

Proteins

Metabolism