FABP6
Domain
Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior. Can bind at least two ligands per molecule, however, the stoichiometry is debated.
Function
Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). In vitro binds to bile acids in the order: deoxycholic acid > cholic acid > chenodeoxycholic acid and respective BA conjugation modifies affinities in the order taurine-conjugated > glycine-conjugated > unconjugated bile acids. Stimulates gastric acid and pepsinogen secretion (By similarity).
Isoform 2
Essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Sequence Similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Tissue Specificity
Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).
Cellular localization
- Isoform 1
- Cytoplasm
- Membrane
- Peripheral membrane protein
- Cytoplasmic side
- Isoform 2
- Cytoplasm
- Localized close to nucleus on the apical side of both normal and neoplastic cells.
Alternative names
ILBP, ILLBP, FABP6, Gastrotropin, GT, Fatty acid-binding protein 6, Ileal lipid-binding protein, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-15P, I-BABP