FAF1

Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis (By similarity).

Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes.

• Nucleus

UBXD12, UBXN3A, CGI-03, FAF1, FAS-associated factor 1, hFAF1, UBX domain-containing protein 12, UBX domain-containing protein 3A

• entrezGene:11124
• omim:604460
• swissprot:Q9UNN5

Proteins

Oncology

73954Da