FAM162A
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity).
Sequence Similarities
Belongs to the UPF0389 family.
Cellular localization
- Mitochondrion membrane
- Single-pass membrane protein
Alternative names
C3orf28, E2IG5, DC16, FWP001, FAM162A, Protein FAM162A, E2-induced gene 5 protein, Growth and transformation-dependent protein, HGTD-P