FAM168B
Function
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the FAM168 family.
Tissue Specificity
Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level). Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level).
Cellular localization
- Cytoplasm
- Perinuclear region
- Cell membrane
- Multi-pass membrane protein
- Cell projection
- Axon
- Expressed in neuronal cell bodies and axonal fibers.
Alternative names
KIAA0280L, MANI, FAM168B, Myelin-associated neurite-outgrowth inhibitor, Mani, p20