FAM3B
Function
Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.
Post-translational modifications
2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.
O-glycosylated.
Sequence Similarities
Belongs to the FAM3 family.
Tissue Specificity
Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.
Cellular localization
- Secreted
- Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.
Alternative names
C21orf11, C21orf76, PRED44, UNQ320/PRO365, FAM3B, Protein FAM3B, Cytokine-like protein 2-21, Pancreatic-derived factor, PANDER