PANDER

Function

Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.

Post-translational modifications

2 N-termini have been observed in the mature protein: the first at Glu-30, resulting from signal peptide cleavage, the second at Ser-46.

O-glycosylated.

Sequence similarities

Belongs to the FAM3 family.

Tissue specificity

Highly expressed in the pancreas. Also found in the colon, kidney, prostate, small intestine and testis.

Cellular localization

• Secreted
• Present in insulin secretory granules and likely cosecreted with insulin. Localized in discrete vesicular and perinuclear structure.

Alternative names

• Protein FAM3B
• Cytokine-like protein 2-21
• Pancreatic-derived factor
• PANDER
• PRED44
• UNQ320/PRO365
• C21orf76
• C21orf11
• FAM3B

Database links

• entrezGene:54097
• omim:608617
• swissprot:P58499

Target type

Proteins

Molecular weight

25982Da