FAM83G
Function
Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways.
Post-translational modifications
BMP signaling induces the phosphorylation by BMPR1A at Ser-610, Ser-614 and Ser-616. Phosphorylation at Ser-610 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS.
Sequence Similarities
Belongs to the FAM83 family.
Cellular localization
- Cytoplasm
- Cytosol
- Nucleus
- Detected predominantly in the cytosol. Upon BMP stimulation, a small portion localizes the nucleus.
Alternative names
PAWS1, FAM83G, Protein FAM83G, Protein associated with SMAD1