FANCG

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

Fanconi anemia complementation group G

FANCG

A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

None

The disease is caused by variants affecting the gene represented in this entry.

Highly expressed in testis and thymus. Found in lymphoblasts.

• Nucleus
• Cytoplasm
• The major form is nuclear. The minor form is cytoplasmic.

XRCC9, FANCG, Fanconi anemia group G protein, Protein FACG, DNA repair protein XRCC9

• entrezGene:2189
• omim:602956
• swissprot:O15287

Proteins

Oncology

68554Da