FARP1
Domain
Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.
Function
Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).
Tissue Specificity
Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Synapse
- Synapse
- Synaptosome
- Cytoplasm
- Cytosol
- Cell projection
- Filopodium
- Cell projection
- Dendrite
- Cell projection
- Dendritic spine
- Recruited to the cell membrane via interaction with CADM1.
Alternative names
CDEP, PLEKHC2, FARP1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2