FARP1

Intramolecular interaction between the DH domain and the PH domains can stabilize the protein in an autoinhibited conformation.

Functions as a guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).

Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.

• Cell membrane
• Peripheral membrane protein
• Cytoplasmic side
• Synapse
• Synapse
• Synaptosome
• Cytoplasm
• Cytosol
• Cell projection
• Filopodium
• Cell projection
• Dendrite
• Cell projection
• Dendritic spine
• Recruited to the cell membrane via interaction with CADM1.

CDEP, PLEKHC2, FARP1, Chondrocyte-derived ezrin-like protein, Pleckstrin homology domain-containing family C member 2, PH domain-containing family C member 2

• entrezGene:10160
• omim:602654
• swissprot:Q9Y4F1

Proteins

Oncology

118633Da