FASN

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

(Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication.

Lipid metabolism; fatty acid biosynthesis.

S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.

Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.

• Cytoplasm
• Melanosome
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

FAS, FASN, Fatty acid synthase, Type I fatty acid synthase

• entrezGene:2194
• omim:600212
• swissprot:P49327

Proteins

Immuno-oncology

273427Da