FASN

Function

Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Post-translational modifications

S-nitrosylation of Fatty acid synthase at cysteine residues Cys-1471 or Cys-2091 is important for the enzyme dimerization. In adipocytes, S-nitrosylation of Fatty acid synthase occurs under physiological conditions and gradually increases during adipogenesis.

Tissue specificity

Ubiquitous. Prominent expression in brain, lung, liver and mammary gland.

Cellular localization

• Cytoplasm
• Melanosome
• Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Alternative names

• Fatty acid synthase
• Type I fatty acid synthase
• FAS
• FASN

Database links

• entrezGene:2194
• omim:600212
• swissprot:P49327

Target type

Proteins

Molecular weight

273427Da