FAT1
Domain
A PTB-like motif (DNXYH sequence) is required for the targeting to the leading edge. This motif represents a minimal protein-protein interaction core motif that is not regulated by tyrosine phosphorylation (By similarity).
Function
Protocadherin Fat 1
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact.
Post-translational modifications
Undergoes proteolytic cleavage. The extracellular domain is cleaved off and the cytoplasmic domain (about 400 AA) shuttles to the nucleus.
Tissue Specificity
Expressed in many epithelial and some endothelial and smooth muscle cells.
Cellular localization
- Protocadherin Fat 1
- Cell membrane
- Single-pass type I membrane protein
- Protocadherin Fat 1, nuclear form
- Nucleus
Alternative names
CDHF7, FAT, FAT1, Protocadherin Fat 1, Cadherin family member 7, Cadherin-related tumor suppressor homolog, Protein fat homolog