Fatty acid-binding protein, liver
Domain
Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.
Function
Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (By similarity). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).
Post-translational modifications
Deamidation and transpeptidation at the beta carboxyl of Asn-105 forms an isoaspartyl residue found in an isoform of the DE-III fraction. This rearrangement gives rise to an extra negative charge carried by the acid form.
Sequence Similarities
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Cellular localization
- Cytoplasm
Alternative names
Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, Squalene- and sterol-carrier protein, Z-protein, p14, L-FABP, SCP, Fabp1