FBPA
Developmental stage
Expressed during parasite asexual blood stages, including in schizonts (at protein level).
Function
Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:26289816). Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (Probable) (PubMed:22991428, PubMed:25261592). Stimulates actin polymerisation (PubMed:25261592).
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Sequence Similarities
Belongs to the class I fructose-bisphosphate aldolase family.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
- Cytoplasmic side
- Host cell membrane
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
PF14_0425, PF3D7_1444800, FBPA, Fructose-bisphosphate aldolase