FBXO22
Function
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function.
Tissue Specificity
Predominantly expressed in liver, also enriched in cardiac muscle.
Cellular localization
- Cytoplasm
- Myofibril
- Sarcomere
- Z line
Alternative names
FBX22, FBXO22, F-box only protein 22, F-box protein FBX22p44