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FBXO42

Function

Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.

Alternative names

FBX42, JFK, KIAA1332, FBXO42, F-box only protein 42, Just one F-box and Kelch domain-containing protein

swissprot:Q6P3S6 omim:609109 entrezGene:54455