FCAR
Function
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Tissue Specificity
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
Cellular localization
- Isoform A.1
- Cell membrane
- Single-pass type I membrane protein
- Isoform A.2
- Cell membrane
- Single-pass type I membrane protein
- Isoform A.3
- Cell membrane
- Single-pass type I membrane protein
- Isoform B
- Secreted
- Isoform B-delta-S2
- Secreted
Alternative names
CD89, FCAR, Immunoglobulin alpha Fc receptor, IgA Fc receptor