FCER2

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003).

Post-translational modifications

N- and O-glycosylated.

The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Tissue Specificity

Detected in urine (at protein level).

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Cell membrane
• Lipid-anchor
• Secreted
• Also exists as a soluble excreted form, sCD23.

Alternative names

CD23, CD23A, CLEC4J, FCE2, IGEBF, FCER2, Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor

Database links

swissprot:P06734 omim:151445 entrezGene:2208

Other research areas

• Immuno-oncology