CD23

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Post-translational modifications

N- and O-glycosylated.

The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Cell membrane
• Lipid-anchor
• Secreted
• Also exists as a soluble excreted form, sCD23.

Alternative names

• Low affinity immunoglobulin epsilon Fc receptor
• BLAST-2
• C-type lectin domain family 4 member J
• Fc-epsilon-RII
• Immunoglobulin E-binding factor
• Lymphocyte IgE receptor
• FCER2
• IGEBF
• FCE2
• CD23A
• CLEC4J

Database links

• entrezGene:2208
• omim:151445
• swissprot:P06734

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

36469Da