Fcer2

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells. On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway.

Post-translational modifications

N- and O-glycosylated.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Cell membrane
• Lipid-anchor
• Secreted

Alternative names

CD23, Fcer2a, Fcer2, Low affinity immunoglobulin epsilon Fc receptor, Fc-epsilon-RII, Lymphocyte IgE receptor

Database links

swissprot:P20693 entrezGene:14128

Other research areas

• Immuno-oncology