Fcgr1
Function
High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Post-translational modifications
N-glycosylated.
Phosphorylated on serine residues.
Sequence Similarities
Belongs to the immunoglobulin superfamily. FCGR1 family.
Tissue Specificity
Macrophage-specific.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Stabilized at the cell membrane through interaction with FCER1G.
Alternative names
CD64, Fcg1, Fcgr1, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, FcRI