FCGR1A

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells.

Phosphorylated on serine residues.

Belongs to the immunoglobulin superfamily. FCGR1 family.

Monocyte/macrophage specific.

• Cell membrane
• Single-pass type I membrane protein
• Stabilized at the cell membrane through interaction with FCER1G.

CD64, FCG1, FCGR1, IGFR1, FCGR1A, High affinity immunoglobulin gamma Fc receptor I, IgG Fc receptor I, Fc-gamma RI, Fc-gamma RIA, FcRI, FcgammaRIa

• entrezGene:2210
• entrezGene:2209
• omim:146760
• omim:601502
• omim:601503
• swissprot:P12314
• swissprot:Q92637
• swissprot:A6NKC4

Proteins

Immuno-oncology

42632Da