FCGR1_HUMAN

Function

High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.

Post-translational modifications

Phosphorylated on serine residues.

Sequence similarities

Belongs to the immunoglobulin superfamily. FCGR1 family.

Tissue specificity

Monocyte/macrophage specific.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein
• Stabilized at the cell membrane through interaction with FCER1G.

Alternative names

• High affinity immunoglobulin gamma Fc receptor I
• IgG Fc receptor I
• Fc-gamma RI
• Fc-gamma RIA
• FcRI
• FcgammaRIa
• FCGR1A
• FCG1
• FCGR1
• IGFR1

Database links

• entrezGene:2210
• entrezGene:2209
• omim:146760
• omim:601502
• omim:601503
• swissprot:P12314
• swissprot:Q92637
• swissprot:A6NKC4

Target type

Proteins

Molecular weight

42632Da