Fcgr2

Domain

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Function

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens.

Post-translational modifications

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD32, Fcgr2b, Fcgr2, Low affinity immunoglobulin gamma Fc region receptor II, Fc-gamma RII, IgG Fc receptor II beta, FcRII

Database links

swissprot:Q63203 entrezGene:116591 entrezGene:25442 swissprot:P27645 entrezGene:304966 entrezGene:289211