FCGR2A

Function

Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.

Post-translational modifications

Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN, HCK and SYK.

Tissue Specificity

Found on monocytes, neutrophils and eosinophil platelets.

Cellular localization

• Cell membrane
• Single-pass type I membrane protein

Alternative names

CD32, FCG2, FCGR2A1, IGFR2, FCGR2A, Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a

Database links

swissprot:P12318 omim:146790 entrezGene:2212 omim:604590 omim:612169 swissprot:P31994 swissprot:P31995 entrezGene:2213 entrezGene:9103