FCGR3B

Function

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Post-translational modifications

Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.

The soluble form is produced by a proteolytic cleavage.

Tissue Specificity

Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.

Cellular localization

• Cell membrane
• Lipid-anchor
• GPI-anchor
• Secreted
• Secreted after cleavage.

Alternative names

CD16b, CD16B, FCG3, FCGR3, IGFR3, FCGR3B, Low affinity immunoglobulin gamma Fc region receptor III-B, Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, CD16-I, Fc-gamma RIII, Fc-gamma RIIIb, FcRIII, FcRIIIb

Database links

swissprot:O75015 omim:610665 swissprot:P08637 entrezGene:2214 omim:146740 entrezGene:2215