FCRL1
Function
Type I transmembrane surface glycoprotein preferentially expressed by B-cells that regulates BCR-mediated signaling responses (PubMed:15479727). Recruits ABL1 as the intracellular effector molecule to enhance B-cell activation (By similarity). Plays also a negative role by suppressing ERK activation under homeostatic and BCR-stimulated conditions in a GRB2-dependent manner (By similarity).
Post-translational modifications
Phosphorylated on tyrosines upon activation.
Tissue Specificity
Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level).
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
Alternative names
CD307a, FCRH1, IFGP1, IRTA5, FCRL1, Fc receptor-like protein 1, FcR-like protein 1, FcRL1, Fc receptor homolog 1, IFGP family protein 1, Immune receptor translocation-associated protein 5, FcRH1, hIFGP1